The official journal of Japanese Society for Medical and Biological Engineering (JSMBE)

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A Basic Study of Osteogenesis between Decellularized Cortical Bone Pieces for Bone Graft Construction

Decellularized porcine cortical bone fragments were implanted to rat subcutaneously. Rat host cells infiltrated to the gap between assembled fragments 1 week after implantation. Two weeks after implantation, the gap was not discernible on X-ray micro CT images, and a bone-like collagen matrix was observed in the gap histologically. These findings suggest that the assembled decellularized bone fragments induce formation of bone matrix to fill the gap in vivo.

Figure. Evaluation of osteogenesis between decellularized cortical bone fragments. (a, d) X-ray micro CT images. (b, c, e, f) H-E stained sections. (c, f) High magnification of b and e. (a-c) 1 week after implantation, (d-f) 2 weeks after implantation. (g) Schematic illustration for formation of bone-like tissue between decellularized cortical bone fragments.

Automatic Image Analysis for Rapid Drug Susceptibility Testing
In recent years, a rapid increase in bacterial strains resistant to modern antibiotics has been observed. This alarming rise in drug-resistant organisms has emphasized the importan...
Andrey Grushnikov, Kazuma Kikuchi, Yoshimi Matsumoto, Takeo Kanade, Yasushi Yagi
Vol. 6 (2017) p. 76-82
Recent Advances in Diagnostic Technologies for Melanoma
Melanoma is a malignant tumor occurring typically in the skin. Advanced melanoma has very poor prognosis, and is also called the “king of cancer”. On the other hand, early-stage me...
Takashi Nagaoka
Vol. 5 (2016) p. 111-117
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The Advanced Biomedical Engineering (ABE) is a peer reviewed online journal covering broad area in biomedical engineering. ABE is officially published by Japanese Society for Medical and Biological Engineering.
ONLINE ISSN: 2187-5219

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