The official journal of Japanese Society for Medical and Biological Engineering (JSMBE)

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A Basic Study of Osteogenesis between Decellularized Cortical Bone Pieces for Bone Graft Construction

Decellularized porcine cortical bone fragments were implanted to rat subcutaneously. Rat host cells infiltrated to the gap between assembled fragments 1 week after implantation. Two weeks after implantation, the gap was not discernible on X-ray micro CT images, and a bone-like collagen matrix was observed in the gap histologically. These findings suggest that the assembled decellularized bone fragments induce formation of bone matrix to fill the gap in vivo.

Figure. Evaluation of osteogenesis between decellularized cortical bone fragments. (a, d) X-ray micro CT images. (b, c, e, f) H-E stained sections. (c, f) High magnification of b and e. (a-c) 1 week after implantation, (d-f) 2 weeks after implantation. (g) Schematic illustration for formation of bone-like tissue between decellularized cortical bone fragments.

Identical Dependence of Dialysate-side Mass Transfer Coefficient on Reynolds Number Using Dimensionless Correlation Based on the Mass Transfer Model in Newly Developed Dialyzers and a Downsized Dialyzer

The dialysis fluid flow and solute removal performance of newly developed dialyzers and a downsized dialyzer were evaluated using a dimensionless correlation equation related to the mass transfer coefficient of the dialysate-side film in a mass transfer model, which was used in quantitative analyses in our previous study.

Makoto Fukuda , Koki Namekawa , Kiyotaka Sakai
Vol. 5 (2016) p. 118-123
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